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Effect of vitamin A and its derivatives on collagen production and chemotactic response of fibroblasts
Author(s) -
HEIN R.,
MENSING H.,
MÜLLER P. K.,
BRAUNFALCO O.,
KRIEG T.
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb04014.x
Subject(s) - fibroblast , chemotaxis , endocrinology , vitamin , medicine , chemistry , tendon , type i collagen , in vitro , microbiology and biotechnology , biochemistry , biology , anatomy , receptor
SUMMARY Vitamin A and several other retinoids were added to fibroblast cultures in order to study possible alterations in biochemical properties and cellular responsiveness. The proliferation of cells was inhibited as the concentration of retinoids increased from 10 ‐9 to 10 ‐5 mol/l. Synthesis of non‐collagenous proteins and production of both type I and type III collagen were decreased. The onset of type III collagen synthesis by tendon fibroblasts in culture was delayed. Furthermore, the chemotactic response of fibroblasts to fibroblast‐conditioned medium was markedly reduced in the presence of retinoids (10 −6 to 10 −12 mol/l).