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Macrophage–T lymphocyte relationships in man's contact allergic reactions
Author(s) -
PANFILIS G.,
GIANNOTTI B.,
MANARA G. C.,
LOMBARDODOMENICI L.,
FERRARI C.,
CAPPUGI P.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb07079.x
Subject(s) - immunocytochemistry , immunology , macrophage , dermis , allergic contact dermatitis , allergen , allergic reaction , lymphocyte , antigen , pathology , allergy , medicine , biology , in vitro , biochemistry
SUMMARY Seventeen biopsies from contact allergic reaction sites in sensitized patients were studied by electron microscopy and immunocytochemistry. Very intimate appositions of macrophages to T lymphocytes were frequently observed in the dermis at 6, 8 and 12 hours after application of the allergen. Such juxtapositions were seen less frequently after 24, 48 and 72 hours. These appositions seem to indicate that macrophages play an antigen‐presenting role in human contact allergic reactions, as Langerhans cells seem to do.