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Abnormal lymphocyte function following long‐term PUVA therapy for psoriasis
Author(s) -
MORISON W.L.,
WIMBERLY J.,
PARRISH J.A.,
BLOCH K.J.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb04597.x
Subject(s) - psoriasis , puva therapy , term (time) , medicine , dermatology , lymphocyte , immunology , physics , quantum mechanics
SUMMARY The surface markers and function of peripheral blood lymphocytes were examined in patients on long‐term therapy with methoxsalen and UV‐A radiation (PUVA). Ten patients with psoriasis were selected because they had received a high exposure to PUVA therapy, i.e., more than 200 treatments over 2–6 years with cumulative exposure doses of 1700–6000 J/cm 2 UV‐A radiation. Results were compared to those obtained with lymphocytes from untreated patients and UV‐B treated patients with psoriasis. The PUVA‐treated patients had low levels of E rosette‐forming cells in the peripheral blood and markedly impaired lymphocyte responses following stimulation with optimal and suboptimal doses of mitogens. The sensitivity of lymphocytes to in vitro treatment with PUVA was similar in the three groups of patients. The results of this study indicate that long‐term PUVA therapy alters the function and cell‐surface markers or distribution of lymphocytes.