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Subcorneal pustular dermatosis and monoclonal IgA
Author(s) -
WALLACH D.,
COTTENOT F.,
PELBOIS G.,
CAVELIER B.,
DIDIERJEAN LILIANE,
SAURAT JEANH.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00344.x
Subject(s) - pathogenesis , epidermis (zoology) , medicine , immunoglobulin a , monoclonal antibody , monoclonal , pathology , dermatology , antibody , immunology , immunoglobulin g , anatomy
SUMMARY A patient with subcorneal pustular dermatosis was found to have a circulating monoclonal IgA kappa immunoglobulin. Direct irnmunofluorcscence studies revealed IgA kappa deposits in the subcorneal zone of the epidermis. Circulating IgA kappa reacting with the subcorneal zone of normal human epidermis was demonstrated by indirect immunofluoresence. It is speculated that IgA deposition might be implicated in the pathogenesis of subcorneal pustular dermatosis.