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Serum and saliva levels of 8‐methoxypsoralen after rectal administration as a micro‐enema
Author(s) -
STOLK L.,
SIDDIQUI A.H.,
KAMMEYER A.,
CORMANE R.H.,
ZWIETEN P.A.
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb15316.x
Subject(s) - saliva , rectal administration , enema , medicine , oral administration , nausea , gastroenterology , serum concentration
Summary Serum and saliva concentrations of 8‐methoxypsoralen (8‐MOP) were determined in seven healthy human volunteers after rectal administration of a micro‐enema. High peak serum levels were reached very soon (0.7±0.3 h) after administration of 8‐MOP. Nausea was not experienced. There was a reasonably good linear correlation between 8‐MOP concentrations in saliva and serum (γ= 0.937). The saliva/serum ratio for 8‐MOP concentration was 0.08±0.02.