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Herpes gestationis and anti‐HLA immunization
Author(s) -
EBERST E.,
TONGIO M.M.,
EBERST B.,
MAYER S.,
BASSET A.
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb08170.x
Subject(s) - human leukocyte antigen , antibody , immunization , medicine , immunology , titer , pregnancy , dermatology , virology , antigen , biology , genetics
SUMMARY The lymphocytotoxicity technique at +15°C and +37°C was used to identify anti‐HLA and cold lymphocytotoxic antibodies in sera from two women with herpes gestationis. The degree of severity of the illness was different in the two cases. The more serious case (widespread cutaneous involvement, repeated fetal deaths) had a very powerful anti‐HLA‐A 9 +anti‐HLA‐B 5 antibody (titre 1/1000); the other had Icss severe skin lesions; she had an anti‐HLA‐B 13 antibody (titre was 1/256). Both cases had cold lymphocytotoxic auto‐antibodies.