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Loss of β 2 microglobulin from the cell surface of cutaneous malignant and premalignant lesions
Author(s) -
TURBITT MARLYN L.,
MACKIE RONA M. M.
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb08164.x
Subject(s) - beta 2 microglobulin , medicine , immunoperoxidase , pathology , lesion , skin lesion , dermatology , antibody , monoclonal antibody , immunology
SUMMARY Biopsies from twenty‐three patients with malignant skin lesions and from twenty‐two patients with premalignant or benign skin lesions were stained for β 2 microglobulin by use of the immunoperoxidase technique. The results showed a significant loss of demonstrable surface β 2 microglobulin from the surface of malignant cells compared to benign, and a partial loss in the premalignant cases. This difference could prove to be a useful tool in the histological diagnosis of malignant skin lesions, and in assessing whether or not the lesion has been completely excised.