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The effect of methotrexate and hydroxyurea on neutrophil chemotaxis
Author(s) -
CREAM J. J.,
POLE D. S.
Publication year - 1980
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1980.tb07655.x
Subject(s) - methotrexate , psoriasis , chemotaxis , motility , pharmacology , epidermis (zoology) , medicine , immunology , chemistry , biology , microbiology and biotechnology , receptor , anatomy
SUMMARY Methotrexate depresses motility of neutrophils in chamber membranes, but does not interfere with random motility in tubes. Hydroxyurea has no such effect. The therapeutic response to methotrexate in psoriasis may be due in part to a reduction in migration of neutrophils into the epidermis.