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An improved rabbit ear model for assessing comedogenic substances
Author(s) -
KLIGMAN A.M.,
KWONG TILLIE
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb08075.x
Subject(s) - ear canal , rabbit (cipher) , anatomy , epidermis (zoology) , hyperkeratosis , pathology , medicine , mathematics , radiology , statistics
SUMMARY A simplified comedogenic assay is described in which test materials are applied for 2 weeks to the ears of rabbits just external to the ear canal. Excised tissue is thus immersed in water at 60°C for 2 min, yielding a sheet of epidermis with microcomedones attached. The magnitude of follicular hyperkeratosis is extracted with the stereomicroscope. Sixteen materials were evaluated by the new and old model which required histological sectioning. Agreement was excellent.