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ADENOSINE 3′: 5′‐CYCLIC MONOPHOSPHATE PHOSPHODIESTERASE IN SKIN
Author(s) -
MIER P. D.,
URSELMANN E.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb16076.x
Subject(s) - phosphodiesterase , medicine , dermatology , library science , family medicine , chemistry , computer science , enzyme , biochemistry
Summary.— The degradation of adenosine 3′: 5′‐cyclic monophosphate (cAMP) to adenosine 5′‐monophosphate by a cutaneous phosphodiesterase has been demonstrated for the first time. The ratio of phosphodiesterase: adenyl cyclase activity in skin is the same as that found in liver and brain. Certain properties of the cutaneous enzyme have been studied; in its solubility, pH curve, K m and sensitivity to methylxanthines it seems very similar to cAMP phosphodiesterases of other tissues. These findings suggest that the current view of cAMP as a “second messenger” in the more active tissues is equally applicable to skin.