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THE EFFECT OF PAKTICLE SIZE AND VEHICLE ON THE PERCUTANEOUS ABSORPTION OF FLUOCINOLONE ACETONIDE.
Author(s) -
BARRETT C. W.,
HADGRAFT J. W.,
CARON G. A.,
SARKANY I.
Publication year - 1965
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1965.tb14578.x
Subject(s) - fluocinolone acetonide , medicine , ophthalmology
WE have shown (Sarkany et al., 1965) that vehicles play a part in the percutaneous absorption of steroids and other topically applied substances. There is, however, no convincing evidence that the particle size of a topically apphed steroid is directly related to its penetration of the skin, although there exists a great deal of experimental and clinical information on the effect of particle size on the gastrointestinal absorption of drugs, particularly griseofulvin (Atkinson et al, 1962).