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An in vitro technique for the rapid determination of drug entry into breast milk.
Author(s) -
Notarianni LJ,
Belk D,
Aird SA,
Bennett PN
Publication year - 1995
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1995.tb04555.x
Subject(s) - breast milk , drug , in vitro , pharmacology , chemistry , mechanism (biology) , medicine , biochemistry , philosophy , epistemology
1. A simple in vitro technique that predicts drug transfer into breast milk is described. 2. Drugs of differing physical and chemical characteristics were tested. 3. The technique provides an experimental system for studying plasma to milk transfer with changing milk composition. 4. A mechanism proposing a role of milk proteins in controlling drug entry into milk is discussed.