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The importance of bradykinin and histamine in the skin response to antigen.
Author(s) -
Warren JB,
Newman CM,
Pixley FJ,
Fuller RW,
Dollery CT
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb05324.x
Subject(s) - terfenadine , histamine , bradykinin , saline , intradermal injection , antigen , endocrinology , pharmacology , enalapril , medicine , immunology , chemistry , receptor , angiotensin converting enzyme , blood pressure
On three separate occasions 12 atopic subjects were injected intradermally with two doses of antigen and one of saline as control. Pretreatment with terfenadine 60 mg orally significantly inhibited the flare response to both the lower dose of antigen and to saline (P less than 0.05). Ingestion of enalapril 5 mg orally 3 h before increased the flare response to both doses of antigen. Neither enalapril nor terfenadine affected the weal response when compared with placebo. Both endogenous histamine and bradykinin appear to be released during the intradermal flare response but are not important in the weal reaction to antigen.