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Bronchodilator activity of a new inhaled beta 2‐adrenoceptor agonist, tulobuterol and its protective effect in exercise‐induced asthma.
Author(s) -
Patel KR
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb05182.x
Subject(s) - bronchodilation , salbutamol , bronchodilator , medicine , asthma , inhalation , agonist , anesthesia , blood pressure , pharmacology , receptor
In fifteen patients with asthma tulobuterol, a new beta 2‐adrenoceptor agonist, given by inhalation in 100 micrograms increments up to a cumulative dose of 600 micrograms produced dose related increases in both the FEV1 and FVC. The bronchodilation was observed within 5 min of the first dose. In a further nine patients tulobuterol 200 micrograms and 400 micrograms aerosol inhibited exercise‐induced asthma following 6‐8 min treadmill exercise and the effect was comparable to 200 micrograms salbutamol aerosol. Minor muscle tremors were observed in two patients with 400 micrograms of tulobuterol but no significant changes in pulse rate or blood pressure were noted.