Paracetamol metabolism in pregnancy. | Zendy

Miners JO | Zendy; Robson RA | Zendy; Birkett DJ | Zendy

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Paracetamol metabolism in pregnancy.

Author(s) -

Miners JO,

Robson RA,

Birkett DJ

Publication year - 1986

Publication title -

british journal of clinical pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.216

H-Index - 146

eISSN - 1365-2125

pISSN - 0306-5251

DOI - 10.1111/j.1365-2125.1986.tb02901.x

Subject(s) - glucuronidation , drug metabolism , metabolism , pregnancy , medicine , acetaminophen , pharmacokinetics , metabolic clearance rate , drug , pharmacology , sulfation , oral administration , chemistry , endocrinology , biochemistry , enzyme , biology , microsome , genetics

Paracetamol disposition was studied in groups of pregnant and non‐ pregnant women of comparable age. Paracetamol apparent oral clearance was 58% higher and elimination half‐life was 28% lower in the pregnant women compared to the control group. The higher clearance in the pregnant women was due to increased activity of the glucuronidation (75% higher) and oxidative (88% higher) pathways of paracetamol metabolism. There was no difference between the two groups in paracetamol sulphation or renal clearance of unchanged drug.

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