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The effect of domperidone on oesophageal emptying in diabetic autonomic neuropathy.
Author(s) -
Maddern GJ,
Horowitz M,
Jamieson GG
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02668.x
Subject(s) - domperidone , medicine , gastric emptying , dysphagia , gastroenterology , heartburn , autonomic neuropathy , diabetes mellitus , gastroparesis , reflux , endocrinology , surgery , stomach , disease , biology , genetics , dopamine , cell culture , neuroblastoma
Oesophageal emptying of solids was studied with a scintigraphic technique in 12 patients with insulin dependent diabetes complicated by autonomic neuropathy and in 22 control subjects. In the diabetics the acute and chronic effects of oral domperidone on oesophageal emptying and symptoms of heartburn and dysphagia were assessed. The number of swallows required to clear the oesophagus in the diabetics (median 9.5, range 2‐30) was significantly greater (P less than 0.001) than in normal controls (median 2, range 1‐14). Domperidone did not increase solid oesophageal emptying in diabetic patients either after acute or after chronic administration.