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Effects of acute administration of brotizolam in subjects with disturbed sleep.
Author(s) -
Roehrs T,
Zorick F,
Koshorek GL,
Wittig R,
Roth T
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02312.x
Subject(s) - medicine , hypnotic , discontinuation , anesthesia , placebo , sleep induction , sleep onset latency , sleep (system call) , insomnia , sleep onset , sleep stages , polysomnography , psychiatry , alternative medicine , operating system , apnea , pathology , computer science
Effects of ingestion of brotizolam (0.25 and 0.50 mg) over 1‐3 days on polysomnographic measures of sleep were assessed in patients complaining of insomnia. Brotizolam reduced latency to sleep, number of awakenings and wake during sleep, and increased total sleep time. It also increased stage 2 sleep and decreased slow wave and rapid eye movement sleep. Increasing the dose from 0.25 to 0.50 mg increased hypnotic efficacy, and there was a more consistent and reliable effect. Discontinuation of brotizolam had minimal effects on sleep compared with placebo over the 3 nights after acute administration. No side‐ effects or disruption of daytime function was found using questionnaires and objective tests of performance.