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Peritoneal absorption of the antibacterial and antiendotoxin taurolin in peritonitis.
Author(s) -
Knight BI,
Skellern GG,
Browne MK,
Pfirrmann RW
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb01292.x
Subject(s) - peritonitis , metabolite , medicine , absorption (acoustics) , gastroenterology , significant difference , abdominal surgery , pharmacokinetics , pharmacology , acoustics , physics
1 Taurolin metabolite plasma concentrations were measured in two groups of patient undergoing abdominal surgery, one group with peritonitis and the other without peritonitis, each group receiving taurolin by intraperitoneal instillation. 2 There was no significant difference in the area under the curves, for the two groups, for one of the metabolites. This would suggest that the absorption of taurolin was not modified in inflammatory conditions such as bacterial peritonitis.