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Animal and molecular pharmacology of mixed agonist‐antagonist analgesic drugs.
Author(s) -
Rance MJ
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb04701.x
Subject(s) - analgesic , pharmacology , agonist antagonist , agonist , antagonist , opiate , drug , buprenorphine , pharmacokinetics , drug action , population , medicine , molecular pharmacology , receptor , clinical pharmacology , opioid , environmental health
1 The pharmacology of analgesic drugs with mixed agonist‐antagonist action is reviewed in the light of the theory of drug action at single and multiple receptors. 2 Evidence for a heterogeneous population of opiate receptors in mammalian brain and in isolated tissue preparations is discussed. 3 The unusual pharmacological and pharmacokinetic profiles of the oripavine derivative buprenorphine are discussed in relation to the action of the drug at a molecular level.