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A comparison of four beta‐adrenoceptor antagonists in patients with asthma.
Author(s) -
Benson MK,
Berrill WT,
Cruickshank JM,
Sterling GS
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb01647.x
Subject(s) - atenolol , acebutolol , pindolol , bronchoconstriction , propranolol , partial agonist , medicine , bronchodilator , heart rate , isoprenaline , agonist , asthma , nadolol , pharmacology , anesthesia , blood pressure , receptor , stimulation
1 Cardiovascular and airways response to two non‐cardioselective beta‐ adrenoceptor blocking drugs, propranolol and pindolol (with partial agonist activity) and two cardioselective beta‐adrenoceptor blocking drugs, acebutolol (with partial agonist activity) and atenolol, were compared in twelve patients with asthma. 2 All four drugs produced a significant reduction in resting pulse rate and prevented the increase in heart rate following inhaled isoprenaline (1,500 microgram). 3 Seven patients in clinical remission showed no significant bronchoconstrictor response to any of the drugs. In the remaining five patients, bronchoconstriction was greatest following propranolol (mean reduction in FEV1 26.6%) and least following atenolol (mean reduction in FEV1 6.5%). 4 The bronchodilator response to inhaled isoprenaline was blocked by propranolol and pindolol but not by acebutolol and atenolol. 5 Partial agonist activity did not appear to be clinically useful.
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