Epidural anaesthesia, ephedrine and phenylephrine in a patient taking moclobemide, a new monoamine oxidase inhibitor | Zendy

Martyr J. W. | Zendy; Orlikowski C. E. P. | Zendy

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Epidural anaesthesia, ephedrine and phenylephrine in a patient taking moclobemide, a new monoamine oxidase inhibitor

Author(s) -

Martyr J. W.,

Orlikowski C. E. P.

Publication year - 1996

Publication title -

anaesthesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.839

H-Index - 117

eISSN - 1365-2044

pISSN - 0003-2409

DOI - 10.1111/j.1365-2044.1996.tb15054.x

Subject(s) - moclobemide , medicine , phenylephrine , ephedrine , anesthesia , monoamine oxidase inhibitor , monoamine oxidase a , clorgyline , monoamine oxidase , serotonin , blood pressure , antidepressant , biochemistry , chemistry , receptor , hippocampus , enzyme

Summary We report a case of low thoracic epidural and general anaesthesia in a patient receiving moclobemide, a new selective inhibitor of monoamine oxidase A. Intra‐operative hypotension was initially treated with phenylephrine and then with ephedrine. The short half‐life of moclobemide and its modest interaction with direct and indirect acting sympathomimetic drugs permit the use of epidural anaesthesia, since any associated hypotension can be safely treated.

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