Antagonists of morphine‐induced respiratory depression | Zendy

GAIROLA R.L. | Zendy; GUPTA P.K. | Zendy; PANDLEY K. | Zendy

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Antagonists of morphine‐induced respiratory depression

Author(s) -

GAIROLA R.L.,

GUPTA P.K.,

PANDLEY K.

Publication year - 1980

Publication title -

anaesthesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.839

H-Index - 117

eISSN - 1365-2044

pISSN - 0003-2409

DOI - 10.1111/j.1365-2044.1980.tb03714.x

Subject(s) - doxapram , medicine , (+) naloxone , morphine , depression (economics) , anesthesia , opiate , respiratory system , respiration , opioid , pharmacology , receptor , anatomy , economics , macroeconomics

Summary This double blind study showed the effect of four drugs, levallorphan, naloxone, doxapram and amiphenazole, on opiate‐induced analgesia and respiratory depression. Satisfactory analgesia was induced by administration of morphine intravenously in a dose of up to 0‐33 mg/kg; such a dose, however, produced significant depression of respiration. Administration of levallorphan, naloxone, and amiphenazole produced reversal of respiratory depression and analgesia. Doxapram reversed the respiratory depression but did not alter analgesia.

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