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[ 13 C]‐pantoprazole breath test to predict CYP2C19 phenotype and efficacy of a proton pump inhibitor, lansoprazole
Author(s) -
FURUTA T.,
KODAIRA C.,
NISHINO M.,
YAMADE M.,
SUGIMOTO M.,
IKUMA M.,
HISHIDA A.,
WATANABE H.,
UMEMURA K.
Publication year - 2009
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2009.04044.x
Subject(s) - lansoprazole , pantoprazole , cyp2c19 , proton pump inhibitor , omeprazole , medicine , dosing , breath test , gastroenterology , pharmacology , helicobacter pylori , metabolism , cytochrome p450
Summary Background 13 CO 2 is produced on metabolism of 13 C‐labelled‐pantoprazole ([ 13 C]‐pantoprazole) by CYP2C19. Aim To investigate whether the [ 13 C]‐pantoprazole breath test can predict CYP2C19 status and efficacy of proton pump inhibitors (PPIs) in Japanese. Methods We classified 110 healthy volunteers as rapid metabolizers (RM), intermediate metabolizers (IM) or poor metabolizers (PM) of CYP2C19 by genotyping. Breath samples were collected at 10‐min intervals for 60 min after dosing with 100 mg [ 13 C]‐pantoprazole. Changes in the carbon isotope ratios ( 13 CO 2 / 12 CO 2 ) in carbon dioxide in breath samples were measured and expressed as a delta‐over‐baseline (DOB) ratio (‰). Of the 110 subjects, twenty‐two randomly selected subjects underwent intragastric pH monitoring on day 7 of dosing with 30 mg of lansoprazole. Results The DOB values of RMs were the highest and those of PMs the lowest of the three groups. Statistically significant differences were observed in the area‐under‐the‐curve ( AUC ) 20–60 min of DOB among the three groups. The mean 24‐h intragastric pHs attained by lansoprazole 30 mg for 7 days were inversely correlated with the AUC 20–60 min of DOB. Conclusions [ 13 C]‐pantoprazole breath test can easily estimate the individual activity of CYP2C19 and predict the efficacy of a PPI (i.e. lansoprazole). This test would be useful for individualized medicine with a PPI.