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Anti‐cyclic citrullinated peptide antibodies in type 1 autoimmune hepatitis
Author(s) -
FUSCONI M.,
VANNINI A.,
DALL'AGLIO A. C.,
PAPPAS G.,
CASSANI F.,
BALLARDINI G.,
FRISONI M.,
GRASSI A.,
BIANCHI F. B.,
ZAULI D.
Publication year - 2005
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2005.02686.x
Subject(s) - medicine , autoantibody , autoimmune hepatitis , rheumatoid arthritis , immunology , rheumatoid factor , antibody , primary biliary cirrhosis , hepatitis c virus , hepatitis , autoimmune disease , arthritis , virus
Summary Background : Besides the autoantibodies included in the diagnostic criteria of type 1 autoimmune hepatitis, many other autoantibodies have been described in this condition. Recently, antibodies against cyclic citrullinated peptide have been validated as specific diagnostic and prognostic markers of rheumatoid arthritis. Aim : To assess whether these antibodies are part of the autoantibody repertoire of type 1 autoimmune hepatitis and correlate with rheumatological manifestations. Methods : Antibodies against cyclic citrullinated peptide were tested by a commercially available enzyme‐linked immunosorbent assay. Results : The antibodies were found in 12 of 133 (9%) type 1 autoimmune hepatitis, two of 49 (4%) with primary biliary cirrhosis, one of 80 (1%) with hepatitis C virus‐related chronic liver disease and 53 of 89 (60%) with rheumatoid arthritis serum samples. High titres were found only in rheumatoid arthritis and type 1 autoimmune hepatitis. No clinical (in particular rheumatological manifestations), biochemical or immunoserological differences were detectable between antibodies against cyclic citrullinated peptide positive and negative type 1 autoimmune hepatitis sera, with the exception of rheumatoid factor, always negative in the positive ones. Conclusions : Antibodies against cyclic citrullinated peptide can be detected in a subgroup of patients with type 1 autoimmune hepatitis. They might be part of the wide range of autoantibody production characteristic of this condition and/or, less probably, be predictive of future rheumatoid arthritis development.