Open Accessγ‐Herpesviruses and cellular signaling in AIDS‐associated malignancies
Author(s) -
Noguchi Kohji,
Fukazawa Hidesuke,
Murakami Yuko,
Takahashi Naoko,
Yamagoe Satoshi,
Uehara Yoshimasa
Publication year - 2007
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2007.00555.x
Subject(s) - carcinogenesis , cancer , virus , immunology , biology , chemotherapy , sarcoma , cancer research , epstein–barr virus , virology , oncovirus , medicine , pathology , genetics
γ‐Herpesviruses, Epstein–Barr virus (EBV/HHV‐4) and Kaposi's sarcoma‐associated herpesvirus (KSHV/HHV‐8), are involved in human carcinogenesis, particularly in immunocompromised patients. Virus‐associated malignancies are becoming of significant concern for the mortality of long‐lived immunocompromised patients, and therefore, research of advanced strategies for AIDS‐related malignancies is an important field in cancer chemotherapy. Detailed understanding of the EBV and KSHV lifecycle and related cancers at the molecular level is required for novel strategies of molecular‐targeted cancer chemotherapy. The present review gives a simple outline of the functional interactions between KSHV‐ and EBV‐viral gene products and host cell deregulated signaling pathways as possible targets of chemotherapy against AIDS‐related malignancies. ( Cancer Sci 2007; 98: 1288–1296)