Open AccessExpression of Integrin α3 in Gastric and Colorectal Cancers: Its Relation to Wall Contraction and Mode of Invasion
Author(s) -
Boku Narikazu,
Yoshida Shigeaki,
Ohtsu Atsushi,
Fujii Takahiro,
Koba Ikuro,
Oda Yasushi,
Ryu Munemasa,
Matsumoto Takeo,
Hasebe Takahiro,
Hosokawa Koichi,
Yamao Takekazu,
Saito Daizo,
Moriya Nobuhiro,
Abe Kaoru
Publication year - 1995
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1995.tb03004.x
Subject(s) - integrin , extracellular matrix , colorectal cancer , medicine , stomach , cancer , contraction (grammar) , metastasis , fibrosis , cancer research , pathology , gastroenterology , biology , receptor , microbiology and biotechnology
We macroscopically classified 25 gastric and 23 colorectal advanced cancers into “contracted” and “uncontracted” types, and found immunohistochemically that integrin subunit α3 was more frequently expressed in the extracellular matrix (ECM) in the former than in the latter (75%:9/12 vs. 38%: 5/13 in gastric and 86%:6/7 vs. 25%:4/16 in colorectal cancers, respectively). Integrin subunit α3 was also expressed more frequently in cancers producing transforming growth factor‐beta (TGF‐β), which is related to ECM deposition, integrin expression and cell mobility, than in those which did not produce TGF‐β (67%:10/15 vs. 40%:4/10 in gastric and 57%:4/7 vs. 38%:6/16 in colorectal cancers, respectively). In addition, integrin subunit α3 was not expressed in 2 benign gastric ulcers combined with gastric cancer elsewhere in the stomach. On the other hand, a retrospective analysis of 107 cases of rectal cancer which recurred after a curative operation revealed that local recurrence was more frequent in “contracted” than “uncontracted” types (44%:ll/25 vs. 26%:21/82). These results may suggest that the abundant interstitial fibrosis which leads to remarkable gastric or colorectal wall contraction is a result of the interaction between cancer cells and ECM, along with the expression of integrin and/or the production of TGF‐β, This fibrosis may also be closely related to the mode of gastric and colorectal cancer invasion.