Synthesis of an Inhibitor of Human Immunodeficiency Virus Infection | Zendy

Hatanaka Kenichi | Zendy; Yoshida Takashi | Zendy; Uryu Toshiyuki | Zendy; Yoshida Osamu | Zendy; Nakashima Hideki | Zendy; Yamamoto Naoki | Zendy; Mimura Toru | Zendy; Kaneko Yutaro | Zendy

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Synthesis of an Inhibitor of Human Immunodeficiency Virus Infection

Author(s) -

Hatanaka Kenichi,

Yoshida Takashi,

Uryu Toshiyuki,

Yoshida Osamu,

Nakashima Hideki,

Yamamoto Naoki,

Mimura Toru,

Kaneko Yutaro

Publication year - 1989

Publication title -

japanese journal of cancer research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.035

H-Index - 141

eISSN - 1349-7006

pISSN - 0910-5050

DOI - 10.1111/j.1349-7006.1989.tb02272.x

Subject(s) - lentinan , sulfation , chemistry , sulfate , pyridinium , in vitro , biochemistry , polysaccharide , medicinal chemistry , organic chemistry

Anti‐HIV effects of lentinan sulfate were investigated by using an HTLV‐I‐carrying cell line, MT–4, in vitro. Lentinan, a fungal branched (1→3)‐β‐ d ‐glucan, was sulfated to various degrees by means of two kinds of procedures using piperidine N‐sulfonic acid in dimetbyl sulfoxide or chlorosulfonic acid in pyridine. Lentinan sulfate with a sulfur content of more than 13.9% effectively prevented HIV‐induced cytopathic effects (CPE) at concentrations of more than 3.3 μg/ml. However, low‐substituted lentinan sulfate did not prevent HIV‐induced CPE at any concentration tested. When the counter‐cation was 50% Na ± and 50% pyridinium ion, the inhibitory capacity was low. Anticoagulant activity of the lentinan sulfate was also assessed.

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