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Activation of the alternative complement pathway by mannose‐binding lectin via a C2‐bypass pathway
Author(s) -
Tateishi Koichiro,
Matsushita Misao
Publication year - 2011
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2011.00378.x
Subject(s) - lectin pathway , mannan binding lectin , alternative complement pathway , complement system , lectin , classical complement pathway , biology , c type lectin , ficolin , mannose , microbiology and biotechnology , biochemistry , immunology , antibody
MBL is a serum lectin that activates the lectin pathway of the complement system. MBL forms complexes with three types of MASPs. Upon binding to Salmonella serogroup C‐specific oligosaccharide, MBL activates the alternative pathway via a C2‐bypass pathway without involving MASP‐2, C2 or C4. We demonstrate that mannan‐bound MBL activates the alternative pathway via a C2‐bypass pathway that requires MASP‐2 and C4. Thus, depending on the ligands to which MBL binds, there may be two distinct MBL‐mediated C2‐bypass pathways.