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Immunostimulating Factor Isolated from Actinobacillus actinomycetemcomitans Stimulates Monocytes and Inflammatory Macrophages
Author(s) -
Jo WolSoon,
Yee SungTae,
Yoon Sik,
Nam ByungHuouk,
Do Eunju,
Jung BeomSeok,
Jeong SooJin,
Hong SookHee,
Yoo YoungHyun,
Kang ChiDug,
Lim YoungJin,
Jeong MinHo,
Lee JaeDong
Publication year - 2006
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2006.tb03823.x
Subject(s) - biology , lipopolysaccharide , immune system , macrophage , actinobacillus , proinflammatory cytokine , microbiology and biotechnology , immunology , mhc class ii , tumor necrosis factor alpha , monocyte , spleen , major histocompatibility complex , inflammation , in vitro , bacteria , genetics , biochemistry
Immunostimulating factor (ISTF) isolated from Actinobacillus actinomycetemcomitans which has been described previously, is distinct from lipopolysaccharide and induces proliferation of B cells. This study was undertaken to investigate whether ISTF might enhance the stimulation of other immune cells. Immunohistochemically, ISTF exhibited a profound stimulating effect on macrophages and dendritic cells as well as B cells in the spleen of BALB/c mice. ISTF was also recognized for its capacity to induce direct activation of mouse macrophages to produce IL‐6, TNF‐α, and NO and MHC class II expression. Therefore, it is postulated that ISTF stimulates macrophages and possibly other cells to produce a wide variety of proinflammatory mediators, which may be involved in the chronicity and tissue destruction of periodontal disease.
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