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Characterization of Monoclonal Antibodies against Hokkaido Strain Tick‐Borne Encephalitis Virus
Author(s) -
Komoro Kimiyo,
Hayasaka Daisuke,
Mizutani Tetsuya,
Kariwa Hiroaki,
Takashima Ikuo
Publication year - 2000
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2000.tb02530.x
Subject(s) - virology , flavivirus , biology , monoclonal antibody , virus , tick borne encephalitis virus , tick borne encephalitis , encephalitis , strain (injury) , antibody , immunology , anatomy
Abstract A tick‐borne encephalitis (TBE) patient was found in Hokkaido in 1993, and TBE viruses were isolated from animals and ticks in our previous studies. To develop a diagnostic reagent to identify TBE viruses, monoclonal antibodies (Mabs) were produced against the TBE virus strain Hokkaido (Oshima 5–10). Seven Mabs were obtained which reacted with the envelope protein of the Oshima 5–10 strain. These Mabs were flavivirus genus‐specific, TBE virus complex‐specific or TBE virus type‐specific. The Mabs are applicable for identification of TBE virus strains.