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Temperature‐Sensitive Growth Mutants as Live Vaccines against Experimental Murine Salmonellosis
Author(s) -
Ohta Michio,
Kido Nobuo,
Fujii Yasuaki,
Arakawa Yoshichika,
Komatsu Takayuki,
Kato Nobuo
Publication year - 1987
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1987.tb01359.x
Subject(s) - mutant , virulence , biology , salmonella , microbiology and biotechnology , salmonella enteritidis , vaccination , attenuated vaccine , virology , bacteria , genetics , gene
Abstract Temperature‐sensitive growth mutants of Salmonella enteritidis , NUB 209 and NUB 323, characterized as protein synthesis mutants, were unable to proliferate at 37 C and lost the parent's virulence. In mice, these mutants conferred high levels of protection as live vaccines. Although the vaccination effect of NUB 323 was not so good as that of NUB 209, NUB 323 was preferred as a safer live vaccine because this mutant was completely avirulent and no back mutation appeared.