Premium
In Vitro Induction of Antibody‐Dependent Cytotoxic Macrophages by the Local Anesthetic Lidocaine
Author(s) -
Kurisu Mariko,
Yamazaki Masatoshi,
Mizuno Den'ichi
Publication year - 1978
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1978.tb00413.x
Subject(s) - phagocytosis , lidocaine , local anesthetic , cytotoxic t cell , cytotoxicity , biology , in vitro , antibody , pharmacology , antiserum , immunology , microbiology and biotechnology , biochemistry , neuroscience
Abstract Normal macrophages were activated to antibody‐dependent cytotoxic effector cells by in vitro treatment with the local anesthetic lidocaine. Experiments on the dose‐response and time course of the effect of lidocaine showed that incubation of normal macrophages with 10 m M lidocaine for 10 min at 28 C was enough for induction of antibody‐dependent cellular cytotoxicity. The activation by lidocaine was accompanied by enhanced phagocytosis of sheep red blood cells (SRBC) sensitized with anti‐SRBC antiserum, but not enhanced ingestion of polystyrene latex particles (PLP). These findings suggest that lidocaine, which has various effects on cell membranes, induces some perturbation of macrophage membranes, resulting in activation of Fc receptor functions in antibody‐dependent cytotoxicity and phagocytosis.