Premium
Urticarial Erythema Associated with IgA Myeloma
Author(s) -
Zhang Yan,
Morita Eishin,
Matsuo Hiroaki,
Ueda Daizo,
Dekio Satoshi
Publication year - 2004
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2004.tb00573.x
Subject(s) - erythema , medicine , serum protein electrophoresis , multiple myeloma , lesion , pathology , bone marrow , immunoglobulin a , bone marrow examination , antibody , dermatology , immunology , monoclonal , immunoglobulin g , monoclonal antibody
Abstract We report a case of atypical urticaria associated with IgA multiple myeloma. A 79‐year‐old man presented with a two‐month history of wheal‐like erythema, which lasted approximately one week without any response to anti‐histamines. Histological examination of a lesion revealed leukocytoclasia as well as perivascular leukocytic infiltration, being consistent with urticarial erythema. Laboratory investigation showed markedly elevated serum IgA concentration and M‐protein in serum protein electrophoresis. A bone marrow examination led to a diagnosis of myeloma. An immunofluorescence study failed to detect any IgA deposit in the lesion. However, the wheal‐like eruptions disappeared when the IgA myeloma was treated and reappeared when it relapsed. We conclude that this long lasting urticaria was the cutaneous manifestation of IgA myeloma.