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Aneurysmal Fibrous Histiocytoma Showing Transition from Factor XIIIa‐Positive to ‐Negative
Author(s) -
Inui Shigeki,
Itami Satoshi,
Yoshikawa Kunihiko
Publication year - 2002
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2002.tb00214.x
Subject(s) - factor xiiia , dermatofibroma , histiocyte , pathology , immunohistochemistry , medicine , stromal cell , transition (genetics) , anatomy , chemistry , biochemistry , gene
Abstract A 39‐year‐old woman visited us because of a subcutaneous induration on her forehead of 7 months' duration. The tumor was tender, firm, and colored blue‐black. Microscopically, the tumor was composed of fibroblastic and histiocytic cells showing no atypicality. In some part intra‐ or extracellular haemosiderin was diffusely seen. There were some blood‐filled spaces of varying size without endothelial lining. From these findings, this case was diagnosed as aneurysmal fibrous histiocytoma (AFH), a variant form of dermatofibroma. Immunohistochemical analysis showed that factor XIIIa‐positive histiocytic cells were distributed in the area without haemosiderin, but such cells were absent in the area with its deposition. Furthermore, the cells near the blood‐filled space showed transition from factor XIIIa‐positive to ‐negative, suggesting that the stromal instability induced by the attenuation of factor XIII may lead the formation of the blood‐filled spaces in AFH.