Premium
Mal de Meleda: A Review of Turkish Reports
Author(s) -
Ayman Taliha,
Yerebakan Özlem,
Yilmaz Ertan
Publication year - 2000
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2000.tb02250.x
Subject(s) - turkish , consanguinity , dermatology , family history , keratoderma , retrospective cohort study , medicine , pathology , pediatrics , hyperkeratosis , philosophy , linguistics
Abstract Keratoderma Palmoplantare Transgrediens or mal de Meleda (MDM) is a very rare, inherited disorder. Its name derives from the island of Meleda. Although, MDM has been reported from many different countries, only two Turkish patients with MDM have been reported in the international literature. Our six cases of MDM are reported, and retrospective analysis of published Turkish patients with MDM is included. We review the clinical characteristics, associated findings, consanguinity, and family history of the cases. In total, 26 Turkish cases of MDM including ours have been documented. Ten cases showed various nail abnormalities, the most common associated feature. We add 24 new cases from Turkey to the list in the literture. Our findings suggest that the MDM gene may also have originated elsewhere than in Mljet.