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THE EFFECTS OF db‐cAMP AND RELATED COMPOUNDS ON THE OUTGROWING EPIDERMIS IN VITRO
Author(s) -
Aoyagi Takashi,
Kamigaki Katsuko,
Iizuka Hajime,
Miura Yusho
Publication year - 1981
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1981.tb02572.x
Subject(s) - epidermis (zoology) , in vitro , intracellular , mitosis , explant culture , mitotic index , inhibitory postsynaptic potential , microbiology and biotechnology , biology , chemistry , medicine , endocrinology , anatomy , biochemistry
Explant cultures of domestic pig skin were used to study the effects of db‐cAMP and related compounds on epidermal outgrowth and mitotic index in the outgrowing epidermis. Db‐cAMP and related compounds which elevated intracellular concentrations of cyclic AMP had inhibitory effects on epidermal outgrowth and mitotic index. Treatment with db‐cAMP in an early “migratory” phase revealed that db‐cAMP inhibited the migratory activities of epidermis in culture.