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TREATMENT OF PEMPHIGUS WITH CORTICOSTEROIDS AND CYCLOPHOSPHAMIDE
Author(s) -
Piamphongsant Thada
Publication year - 1979
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1979.tb01927.x
Subject(s) - pemphigus vulgaris , cyclophosphamide , pemphigus , pemphigus foliaceus , prednisolone , prednisone , medicine , dermatology , antibody , immunology , titer , gastroenterology , chemotherapy , autoantibody
ABSTRACT An initial combination of moderated doses of prednisone or prednisolone and cyclophosphamide seemed to be rapidly effective in controlling pemphigus vulgaris and pemphigus foliaceus with minimal side effects. An appropriate schedule of treatment is proposed. The clinical response correlated very well with the decreased titers of pemphigus antibodies which became negative within six months. Elevated serum immunoglobulin levels returned to normal in most of the cases.