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Induction of spermiation in common carp after enhanced intestinal uptake of sGnRH‐A and Pimozide
Author(s) -
Roelants I.,
Mikolajczyk T.,
Epler P.,
Ollevier F.,
Chyb J.,
Breton B.
Publication year - 2000
Publication title -
journal of fish biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 115
eISSN - 1095-8649
pISSN - 0022-1112
DOI - 10.1111/j.1095-8649.2000.tb02152.x
Subject(s) - pimozide , milt , biology , carp , endocrinology , medicine , common carp , hormone , oral administration , cyprinus , pharmacology , fish <actinopterygii> , fishery , dopamine , haloperidol
The inherent ability of the carp Cyprinus carpio gut to absorb intact salmon gonadotropin hormone‐releasing hormone analogue (sGnRH‐a)+Pimozide (Pim), without loss of their bioactivity is very limited. Artificial intestinal absorption enhancement boosted sGnRH‐a and Pim induced GtH II release and milt production significantly. The intraperitoneal route of administration was more effective than the oral one. A potential application of the oral route for peptidergic drug delivery and the possibility of developing a dietary delivery system is discussed.