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Immunologic profile in chronic inflammatory polyneuropathies associated or not associated with MGUS
Author(s) -
Santuccio G,
Sanvito L,
Speciale L,
Merlino L,
Sgandurra M,
Ceresa L,
Ferrante P,
Nemni R
Publication year - 2004
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/j.1085-9489.2004.009209i.x
Subject(s) - monoclonal gammopathy of undetermined significance , cd8 , cd14 , cd19 , interleukin 10 , immunology , flow cytometry , medicine , cd3 , cytokine , antigen , monoclonal , monoclonal antibody , antibody
Chronic inflammatory polyneuropathies (CIP) may be associated with monoclonal gammopathies (MGUS) directed or not against neuropathy‐related antigens. We analysed peripheral T and B cell subsets and cytokine network in 13 patients with CIP without MGUS (CIP), 10 with CIP with MGUS anti‐MAG (CIP‐MAG) and 5 with CIP with MGUS without anti‐MAG activity (CIP‐MGUS). We evaluated, by flow cytometry, CD3+, CD3 + DRII+, CD4+, CD8+, CD16+ and CD19+ cells subset distribution, and intracellular IL2, INFg, IL1, IL6, IL10 and TNFa production by CD4+, CD8+ and CD14+ cells. Results were compared with age‐matched healthy controls (HC); statistical analysis was performed. Compared to HC, CIP patients had a significant decrease of CD3+ and B cells, CIP‐MAG patients had an increase of CD3+ and NK and a decrease of CD3 + DRII+ and B cells. Comparing the different subgroups, we found a decrease of CD3 + DRII+ and B cells in CIP‐MAG versus CIP, and an increase of CD4+ in CIP‐MGUS versus CIP. Compared to HC, CIP showed an increase of INFg in CD4+ and of IL6 in CD14+. CIP‐MAG showed an increase of IL10 in CD4+, IL1 and IL10 in CD8+, and IL1 in CD14+, versus HC and other subgroups. Our results suggest that in CIP‐MAG patients it is possible to identify a distinct immunological profle.

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