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Effect of Oxygen Plasma Treatment for Cell Adhesion Properties on Silicone Surface
Author(s) -
Ohsugi Ikuko,
Yamada Tai,
Inoue Yoshikazu,
Mizuno Kiyoyuki,
Okumoto Takayuki,
Yoshimura Yohko
Publication year - 2005
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2005.130116q.x
Subject(s) - silicone , biocompatibility , adhesion , cell adhesion , fibroblast , surface modification , coating , biomedical engineering , chemistry , materials science , composite material , medicine , in vitro , organic chemistry , biochemistry
Aim: The silicone polymer is known to be useful and safety as a material of medical implants. But fundamentally its biocompatibility and biostability are questionable. Thus we try to make a hybrid‐type silicone implant coating by cell layers. At first, we aimed to confirm cell adhesion and growth on silicone surface. Material: Group 1 is silicone implants for the augmentation rhinoplasty with no treatment. Group 2 is same type silicone implants with surface modifications by O 2 plasma treatment (3 min). Group 3 is the group 2 implants with serum and plasma coating (20 min). Method: We co‐cultured materials of each group with human fibroblast (2.4*10 4 cells/ml), for 17 hours, with 5%CO 2 , in the temperatures of 37 °C. Results: Group 1; none of fibroblasts could take the surface of materials. Group 2; several fibroblasts were found on the surface of those. Group 3; much more fibroblasts were found than group 2 This result means that the surface modification by O 2 plasma treatment itself enables the cell adhesion and growth on silicone surface.