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P‐I‐01
Treatment of Skin Defects and Skin Ulcers with bFGF Preparation
Author(s) -
Akihiro Ogino,
Kiyoshi Onishi,
Hiroko Yoshida,
Yu Maruyama
Publication year - 2004
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2004.abstractn.x
Subject(s) - medicine , granulation tissue , basic fibroblast growth factor , refractory (planetary science) , therapeutic effect , wound healing , dermatology , drug , surgery , pharmacology , growth factor , biology , receptor , astrobiology
On 11 patients with skin defect and refractory ulcer, treatment was conducted using bFGF preparations. Good granulation, epithelialization and reduction of ulcer were observed in all patients by once‐daily spraying of this product after washing the topical region. This preparation is a drug developed aiming at the basic fibroblast‐proliferating factor playing an important role in the wound healing process in the body and expecting the therapeutic effects on refractory skin ulcer. Although there are some restrictions including the tropical conditions such as infection and adherence of necrosed tissues and careful administration to the patients with a past history of malignant tumor, its good therapeutic effects were expected in the patients ineffective with other drugs, and this product was evaluated to be useful from the viewpoint of QOL, such as shortening of treatment period, reduction of cost and low invation.