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Celosia Argentea Linn. Leaf Extract Improves Wound Healing in Rat Burn Wound Model
Author(s) -
Priya Kulasekaran S,
Babu Mary,
Wells Alan
Publication year - 2004
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1067-1927.2004.0abstracted.x
Subject(s) - wound healing , granulation tissue , traditional medicine , burn wound , medicine , chemistry , surgery
Celosia argentea is used in traditional medicine for sores, ulcers, and skin eruptions. Therefore, we investigated the healing efficiency of an ointment formulated on a alcohol extract of Celosia argentea leaves (CA) in a rat burn wound model. Wound closure occurred earlier in the treated rats (15 days versus 30 in the untreated group; P < 0.05). Collagen and hexsoamine content of the granulation tissue increased at a faster rate in the treated wounds. To probe the cell biologic basis of this effect, we found that this extract promoted cell motility and proliferation of primary dermal fibroblasts but did not alter these responses in primary keratinocytes. In short, we demonstrate a salutary action of the Celosia argentea extract on wound healing and suggest that this may be due to mitogenic and motogenic promotion of dermal fibroblasts.