Factors influencing sensitivity of a rapid influenza diagnostic test in a community‐based population of kindergarten through 12th‐grade students: Wisconsin 2015–2020

Rapid influenza diagnostic tests (RIDTs) have variable sensitivity. In a community‐based population of kindergarten through 12th‐grade (K‐12) students, we assessed factors that may influence RIDT performance using 2368 paired results from Sofia® influenza A + B fluorescent immunoassay and reverse transcription polymerase chain reaction (RT‐PCR). RIDT sensitivity and specificity were 76.1% (95% CI: 72.8–79.1) and 97.2% (96.2–97.9), respectively. Factors associated with sensitivity included runny nose (OR = 3.0, p  < 0.001), nasal congestion (1.59, p  = 0.045), days from symptom onset (per day; 0.75; p  < 0.001), myalgia (0.61; p  = 0.014), age (per 5 years; 0.55; p  = 0.001), and detection of another virus (0.50; p  = 0.043). Understanding these factors can aid in interpreting negative results.