Premium
Fibroblasts and macrophages: Collaborators in tissue homeostasis
Author(s) -
Franklin Ruth A.
Publication year - 2021
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12989
Subject(s) - biology , microbiology and biotechnology , motility , immune system , homeostasis , cell type , secretion , context (archaeology) , cell , cell signaling , immunology , signal transduction , genetics , paleontology , biochemistry
Abstract Fibroblasts and macrophages are universal cell types across all mammalian tissues. These cells differ in many ways including their cellular origins; dynamics of renewal, recruitment, and motility within tissues; roles in tissue structure and secretion of signaling molecules; and contributions to the activation and progression of immune responses. However, many of the features that make these two cell types unique are not opposing, but instead complementary. This review will present cell‐cell communication in this context and discuss how complementarity makes fibroblasts and macrophages highly compatible partners in the maintenance of tissue homeostasis.