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Neuropathic ulcers: a focused review
Author(s) -
Urso Brittany,
Ghias Mondana,
John Anan,
Khachemoune Amor
Publication year - 2021
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.15362
Subject(s) - medicine , neuropathic pain , diabetes mellitus , amputation , peripheral neuropathy , diabetic foot , disease , arterial disease , intensive care medicine , pathophysiology , vascular disease , surgery , dermatology , anesthesia , endocrinology
Abstract Neuropathic ulcers or diabetic foot ulcers are preventable ulcers associated with diabetes mellitus. These ulcers occur in the setting of unrecognized trauma, peripheral neuropathy, and foot deformities; however, they are often complicated by peripheral arterial disease and infection. Approximately 15% of individuals with a neuropathic ulcer require limb amputation as a result of infection. Not only are neuropathic ulcers a burden to the patient but also to the economy. The cost of diabetic foot ulcer care is approximately $1.38 billion per year. This makes neuropathic ulcers an important therapeutic target. This review presents the pathophysiology, clinical presentation, evaluation, management, and prevention of neuropathic ulcers.