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Novel murine tumour models depend on strain and route of inoculation
Author(s) -
Fu Qiang,
Satterlee Andrew,
Wang Yongjun,
Wang Yuhua,
Wang Dun,
Tang Jingling,
He Zhonggui,
Liu Feng
Publication year - 2016
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/iep.12192
Subject(s) - inoculation , strain (injury) , mouse strain , ratón , subcutaneous injection , neoplasm , biology , intraperitoneal injection , immunology , pharmacology , genetics , bioinformatics , anatomy , gene
Summary This study describes variations in tumour growth patterns which occur when changes in the routes of inoculation and mouse strain are used to introduce tumours into established murine model systems that are known to vary in location and aggression. Intraperitoneal, subcutaneous, intravenous and hydrodynamic inoculations of B16F10 cells were compared among CD ‐1, C57 BL /6 and Balb/c mice. Most surprisingly, allogeneic tumour growth in Balb/c mice after intravenous and hydrodynamic inoculation of B16F10 cells was faster than tumour growth in the syngeneic C57 BL /6 mice. These and other variations in the tumour growth patterns described here can help provide the researcher with more experimental control when planning to use the optimal tumour model for any particular study.