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Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation
Author(s) -
Lau ChingIn,
Yánez Diana C.,
Papaioannou Eleftheria,
Ross Susan,
Crompton Tessa
Publication year - 2022
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.16222
Subject(s) - sonic hedgehog , morphogen , inflammation , immunology , atopic dermatitis , microbiology and biotechnology , hedgehog signaling pathway , barrier function , thymic stromal lymphopoietin , asthma , biology , disease , medicine , pathology , signal transduction , genetics , gene
Epithelial barrier tissues such as the skin and airway form an essential interface between the mammalian host and its external environment. These physical barriers are crucial to prevent damage and disease from environmental insults and allergens. Failure to maintain barrier function against such risks can lead to severe inflammatory disorders, including atopic dermatitis and asthma. Here, we discuss the role of the morphogen Sonic Hedgehog in postnatal skin and lung and the impact of Shh signalling on repair, inflammation, and atopic disease in these tissues.