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Inflammasome activation by nucleic acids and nucleosomes in sterile inflammation… or is it sterile?
Author(s) -
Lupfer Christopher R.,
Rodriguez Angeline,
Kanneganti ThirumalaDevi
Publication year - 2017
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14076
Subject(s) - inflammasome , inflammation , aim2 , innate immune system , nucleic acid , biology , nucleosome , hmgb1 , histone , immune system , microbiology and biotechnology , immunology , acquired immune system , genetics , dna
Inflammasomes are multiprotein complexes that form in the cytoplasm in response to cellular damage and cytosolic pathogen‐associated molecules during infection. These complexes play important roles in initiating innate and adaptive immune responses to infectious disease. In addition, inflammasomes are now recognized as important mediators of sterile inflammation in various autoimmune and autoinflammatory diseases. Interestingly, microbiota and infection play critical roles in the development of ‘sterile inflammation’. Herein, we highlight recent advances in our understanding of the role for inflammasomes in nucleic acid‐, nucleosome‐, and histone‐driven sterile inflammation and discuss knowledge gaps and areas of potential future research.