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Decreased serum levels of interleukin‐17, interleukin‐23, TGF ‐β in pemphigus vulgaris patients, and their association with disease phase
Author(s) -
Gholibeigian Zeinab,
Izad Maryam,
Daneshpazhooh Maryam,
Mortazavi Hossein,
Salehi Zahra,
Behruzifar Shirin,
Akhdar Marwa,
Tavakolpour Soheil,
Azizpour Arghavan
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.14071
Subject(s) - pemphigus vulgaris , pathogenesis , medicine , interleukin 17 , interleukin , immunology , transforming growth factor , interleukin 6 , cytokine , interleukin 23 , disease
Abstract The exact pathogenesis of Pemphigus Vulgaris (PV) has remained unclear, but it seems that cytokines play critical roles in this disease. This study aims to assess the serum levels of interleukin (IL)‐6, IL‐17, IL‐23, and TGF‐β in PV patients and compare the results to the healthy controls. Serum levels of IL6, IL‐17, IL‐23, and TGF‐β were successfully determined by enzyme‐linked immunosorbent assay (ELISA) in 27 newly diagnosed PV, 32 patients in remission, and 29 healthy controls. It was shown that the mean serum levels of IL‐17, IL‐23, and TGF‐β serum are significantly different among the PV patients and healthy controls ( P values: <.001, .001, and .003, respectively). It was found that new PV patients have lower serum levels of IL‐17, IL‐23, and TGF‐β as compared to healthy controls ( P values: <.001, <.001, and .003, respectively). Regarding IL‐6, no significant difference was observed between the healthy controls and the other two groups of patients. IL‐17, IL‐23, and TGF‐β are involved in the pathogenesis of PV. However, more studies are required to clarify their exact roles in the immunopathogenesis of PV.