Open AccessFibroblast growth factor 22 is a novel modulator of depression through interleukin‐1β
Author(s) -
Xu YuHao,
Yu Ming,
Wei Hong,
Yao Shun,
Chen SiYuan,
Zhu XiaoLan,
Li YueFeng
Publication year - 2017
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12760
Subject(s) - hippocampal formation , fibroblast growth factor , hippocampus , interleukin 6 , interleukin , apoptosis , depression (economics) , endocrinology , medicine , tumor necrosis factor alpha , cytokine , neuroscience , immunology , chemistry , biology , biochemistry , receptor , economics , macroeconomics
Summary Background and Aims Emerging evidence shows that fibroblast growth factor 22 ( FGF 22) plays a critical role in the etiology of depression. However, the molecular mechanisms of FGF 22 are not fully comprehended. Here, the effect of FGF 22 in depression and its relationship with interleukin‐1β ( IL ‐1β) were investigated in clinical, animal, and cell experiments. Methods Serum from depressive patients was collected, and the levels of FGF 22 and IL ‐1β were analyzed by ELISA . The chronic unpredictable mild stress ( CUMS ) model was established, and primary hippocampal neuronal cells were cultured to examine changes in FGF 22 and IL ‐1β levels in rat hippocampus. Results The results revealed a negative correlation between serum FGF 22 levels and serum IL ‐1β levels. The expression of IL ‐1β in the CUMS rat hippocampus decreased, and the apoptosis of hippocampal cells improved after the injection of lentiviral vector‐mediated FGF 22 ( LV ‐ FGF 22). Further tests in primary hippocampal neuronal cells also showed a reduction in IL ‐1β and the cell apoptosis rate after treatment with FGF 22. Conclusion In conclusion, the results revealed that FGF 22 plays a role in alleviating depression, which may be mediated by reduced expression of IL ‐1β.